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Gliptins may represent a valuable alternative to a sulfonylurea or a glitazone after failure of monotherapy with metformin while GLP-1 receptor agonists may be considered as a good alternative to insulin (especially in obese patients) after failure of a dual oral therapy

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Notably, these advantages persisted irrespective of baseline kidney function, HbA1c levels, BMI, the timing of DM diagnosis, comorbidities and concurrent medication, including immunosuppressants (Fig

After each dose increase, you may experience a mini-return of side effects, usually milder than what you experienced initially